Une makore mangani chaizvo? Ziva zera rako rekubereka 714x5h

Zera rinotorwa senhamba - uye nhamba inogona kuchinja. Iri ndiro zano rakakurudzirwa neTally Health, kutanga kutsva kuri chikamu cheboka remakambani anotengesa bvunzo dzinopa vatengi ruzivo nezve yavo "biological age". x3056

Chii chinonzi biological age test 2f474s

Makambonzwa nezvebvunzo dzekumba sedziya dzinobva 23andMe, Ancestry kana kubva Generaque tarisa DNA yako kupa ruzivo nezve nhaka yedzinza uye njodzi dzehutano? Ikozvino mafungu ekutanga ari kutengesa bvunzo dzinoti ongorora ropa rako, weti kana cheek swab (swab muunganidzwa wemajini) kuratidza zera rako rekubhaibheri.

Iwo maedzo anoyera epigenetic mapatani, kana shanduko mumuviri inokanganisa maitiro emajini. Kusiyana nezera rekuverenga nguva, iro rinofambira mberi pamwero wakafanana kune wese munhu, zera rebhayoloji ndiko kumhanya uko maseru, matishu uye nhengo dzinoita sedziri kudzikira — uye izvi zvinogona kusiyana zvichienderana nenhoroondo yehutano hwemunhu.

Mashandiro anoita bvunzo yeTally Health 22s3f

A Tally Health, ichangobva kutangwa, ndeimwe yemakambani gumi nemaviri anopa bvunzo dzekuongorora zera remuviri rekubereka. Kambani co-muvambi, Harvard University biologist David Sinclair, anotsanangura bvunzo se chikamu chechikwereti chemuviri. Mushandisi anotora cheek swab, anotumira sampuli netsamba uye kambani inodzorera zera ravo rekubereka.

Sinclair anotsanangura kuti kana mhedzisiro ikaratidza kuti mushandisi mudiki, hombe, zano nderekuvachengeta vari vadiki uye kunyange kuvatsidzira pavanenge vachikura vachitevedzana. Nekune rumwe rutivi, kana mhedzisiro inoratidza zera rebhaibheri rakura kupfuura zera rekurongeka, kambani iripo kuti idzore mamiriro ezvinhu aya, ichiita kuti zera rehupenyu risangodzokera kuavhareji, asi pasi payo.

Zvinhu zvinokanganisa zera rehupenyu r2z5p

Zvose zviri zviviri genetics uye mararamiro anobatsira pakukwegura. Sarudzo dzakadai sekudya, kurovedza muviri, fodya uye kunwa doro zvinokonzeresa epigenetic shanduko inokanganisa maitiro emajini. Pamusoro pezvo, kuratidzwa kushushikana, kushungurudzika, uye kusvibiswa kunogona kuve nemhedzisiro yakaipa.

Masayendisiti anotenda kuti kuunganidzwa kwezvinhu zvese izvi kunokanganisa zera remunhu, asi Sinclair anotenda kuti genetics haina kukosha zvakanyanya pane izvo zviri mukutonga kwemunhu. (Sinclair ane makore makumi mashanu nematatu, asi sekuongororwa kweTally Health, zera rake rekubereka rakafanana neane makore makumi mana nematatu.)

David Sinclair 2r1f5v

David Sinclair muongorori ane mukurumbira mumunda wehupenyu hurefu uye anti-kuchembera. Anozivikanwa nokuda kwake research pa resveratrol, musanganiswa uripo mumazambiringa matsvuku anonzi “chishamiso molecule”. Zvisinei, vamwe vatsvakurudzi vakadaro maonero akasiyana nezve mabhenefiti angangodaro eresveratrol, kunyanya mukuedzwa kwemhuka.

Pasinei neizvi, Sinclair tora zuva nezuva resveratrol supplements uye anoenderera mberi nekudzidza zvazvinoita murabhoritari yake paHarvard. Pamusoro pekutsvagisa kwake, akavambawo makambani akati wandei ebiotechnology akatarisana nehupenyu hurefu, uye bhuku rake ra2019, "Lifespan: Nei Tichichembera-uye Nei Tisingafanire Kuita," rakave mutengesi weNew York Times.

Zvatiri kuedza kuita, pamwero wepamusoro, kuchinja nzira yatinochembera nayo.

Melanie Goldey, CEO weTally Health.

Kambani yeNew York-based Tally Health inopa sevhisi kupfuura kupa zera rebiological remutengi wega wega. Iyo kambani inopa chirongwa chekuita ne kurudziro yemararamiro emunhu, kufanana nekurara zvakanyanya, kupedza nguva shoma wakagara, kuderedza kushungurudzika, kana kudya miriwo yakawanda - zvinhu izvo vanhu vakawanda vanogona kubatsirwa nazvo.

Mitengo uye kudiwa 6m1p5b

Vashandisi vanogona kusarudza pakati pebvunzo imwe chete yeUS$229 (R$1520,39) kana kuwana kunyoresa kuti vaedze mwedzi mitatu yega yega uye kuona zera ravo rekuzvarwa nekufamba kwenguva. Sekureva kwaGoldeny, mutauriri wekambani, "tinofunga kuti ino inguva yakanaka yekuti vanhu vawane hurongwa hwavo hwekuita, vazvipe simba neruzivo, vasarudze kugadzirisa kwavanoda kuita uye kuita shanduko."

Anoshuma kuti Tally Health yaive nechido chakasimba pakuvhurwa, paine runyorwa rwakamirira rwevanhu vanopfuura zviuru mazana maviri nemakumi manomwe. Zvakadaro, kambani iyi haina kuburitsa huwandu hwevanhu vakasaina kusarudzwa kwenhengo, kubva paUS$270.000 (R$129) kusvika paUS$655,95 (R$199) pamwedzi.

Sezvo mamwe epigenetic kuchembera bvunzo iripo pamusika, Tally Health inoongorora DNA methylation mapatani, iwo ma tag emakemikari muDNA kodhi anokanganisa chiitiko chejeni. Hukama huri pakati peDNA methylation uye kuchembera hwakagadzwa nevasayendisiti muma1970.

Epigenetic kuchembera wachi 6g4s11

Muna 2013, Steven Horvath, geneticist uye biostatistician kuUCLA, akagadzira yekutanga. kuchembera "clock" epigenetics yakavakirwa pane shanduko idzi. Wachi bvunzo yekufembera inoshandisa data kubva ku8.000 biological samples kubva makumi mashanu nemumwe ane hutano hwevanhu uye maseru marudzi kuyera DNA methylation maitiro ane chekuita nekuchembera uye chirwere, uye inoshandisa algorithm kufungidzira zera remunhu.

Chizvarwa chitsva chewachi epigenetic chinangwa chekufanotaura kwete chete zera rehupenyu, asiwo tarisiro yehupenyu uye hutano hweramangwana. O PhenoAge, yakagadzirwa naMorgan Levine weYale University muna 2018, inoshandisa masampuli eropa ku kuverenga njodzi yekufa zvakazara, pamwe nenjodzi yegomarara, chirwere chemoyo uye Alzheimer's.

Muna 2019, timu inotungamirwa naSteven Horvath naAke Lu yakagadzira iyo GrimAge, shanduro yakagadziridzwa yekare epigenetic wachi inogona kufanotaura tarisiro yeupenyu yemunhu kubva pakuongororwa ropa.

Wachi idzi dzakagadzirwa kuti dzishandiswe nevatsvakurudzi vane chinangwa chekuongorora maitiro ekurwisa kuchembera kwezvinhu kana shanduko yemararamiro mumhuka kana vanhu. Maererano ne zvidzidzo yakagadzirwa, zvakaonekwa kuti vaya vane zera rakakwirira rokurarama maererano nezera ravo rokuverengwa kwenguva ndivo vanotapurwa nezvimwe zvirwere norufu. Nekuda kweizvozvo, makambani anobuda aine chinangwa chekugadzira iwo ega wachi kana kugadzirisa aripo kuti aedze zvakananga kune vatengi.

Tally Hutano uye zvimwe zviedzo zviripo pamusika 1a6q11

Tekinoroji yakashandiswa muTally Health bvunzo yakagadziriswa murabhoritari yeSinclair paHarvard University uye yakatsanangurwa mu chinyorwa chakafanotaurwa yakaburitswa gore rapfuura.

Nekuunganidza maseru aripo mumuromo swab, kambani inokwanisa kufungidzira zera remunhu rekuzvarwa, kuongorora maDNA methylation mapatani uye nekuaenzanisa nemasampuli kubva kuvanhu zviuru zvisere, vane makore ari pakati pe8.000 ne18 makore, akaunganidzwa nekambani. Sekureva kwaGoldeny, hafu yemasampuli yakatorwa kubva kuvarume uye imwe hafu kubva kuvakadzi, nepo makumi matatu kubva muzana kubva kune vasiri vachena.

Kune dzimwe bvunzo dziripo pamusika: Kubva 2017, kambani yeIrvine, California-yakavakirwa Zymo Research yakapa ongororo yeropa kana weti inonzi. myDNAge yeUS$299 (R$1521,22), zvichibva pawachi yekuchembera yeHorvath. Iyo kambani inopa a tsika report iyo inosanganisira ruzivo nezvehutano hwemetabolism yemutengi, chiitiko chemethylation, uye njodzi inogona kuitika yezvirwere zvine chekuita nezera.

Muna 2019, mugadziri wezvekuwedzera weNew York City Elysium Health akatanga bvunzo yekuchembera yebiological yemadhora mazana maviri nemakumi mapfumbamwe neyakagadzirwa pamwe chete naLevine, anoshanda pari zvino. Altos Lab, iyo $3 bhiriyoni yekuwedzera hupenyu kambani muSan Diego.

Kusava nechokwadi uye zvidzidzo 5he5j

Vamwe vanhu vanokura zvishoma nezvishoma uye vanorarama hupenyu hurefu, hune hutano, asi vamwe vanokura nekukurumidza uye vane kutanga kwechirwere chisingaperi. Zera rebiological inzira yekuyedza kupfupisa misiyano iyi pakati pevanhu.

Daniel Belsky, purofesa wezve epidemiology paColumbia University

Sekureva kwaBelsky, hazvisati zvanyatso zivikanwa kana ikozvino epigenetic bvunzo inonzwisisika zvakakwana kuti ione shanduko yehupenyu iyo vanhu vanogona kuita munguva pfupi.

Kunyangwe vachikwanisa, bvunzo dzinodzokororwa hadzisati dzaitwa pane vanhu vakakwana kuti vaone kana zvibodzwa zvavo zvichienderana nekuchinja kwehutano hwavo hwese uye hupenyu hurefu. Sekureva kwaBelsky, "hatisati tanyatsonzwisisa mashandisiro avanoita sevatariri vekufambira mberi kwemunhu."

Kudzidza nezvekudya 2c86w

Numeri ongororo yazvino Yakaitiswa naBelsky nevamwe vake paYunivhesiti yeColumbia, yakaongororwa kana kudya kwakaderera-calori kunogona kuva nemigumisiro yekurwisa kukwegura muvanhu. Kuti vaite izvi, vanhu vakuru vane hutano vakasarudzwa kuti vatore chikamu mukuedza kwekiriniki yemakore maviri, yakakamurwa kuva mapoka maviri: imwe yaitevera kudya kwemazuva ose uye imwe yakatevera kudya kunorambidzwa ne25% yemakori.

Munguva yekudzidza, sampuli dzeropa dzakaunganidzwa kubva kune vatori vechikamu pakutanga, gore rimwe gare gare uye pakupedzisira, vachishandisa matanho matatu ekuongorora kuchembera: PhenoAge, GrimAge uye wachi yakagadzirwa naBelsky uye vashandi vanonzi. DunedinPACE, iyo inofungidzira kuchembera kwomunhu.

Migumisiro yezvokudya 4d3k

Iyo PhenoAge uye GrimAge wachi yakawana kuti calorie restriction haina kukosha pazera rokubereka kwomunhu. Nekudaro, muyedzo weDunedinPACE wakaratidza kuti kudya kwacho kwakaderedza mwero wekuchembera.

Belsky akatsanangura kuti "zvimwe zvezvishandiso izvi zvinogona kunge zvisina kugadzirwa kuti zvione shanduko diki muzera rekubereka." The company TruDiagnostic, iri muKentucky, inotengesa DunedinPACE seyedzo yevatengi.

Charles Dupras, a bioethicist paYunivhesiti yeMontreal uyo akatsvaga zvakananga-kune-vatengi epigenetic bvunzo, akati bvunzo dzakadai dzinogona kubatsira vanhu nekushanda se kurudziro yekutora miitiro ine hutano.

"Kuwana chishandiso ichi kunogona kuve sosi yakanaka yekukurudzira vanhu."

Charles Dupras, bioethicist paYunivhesiti yeMontreal.

Nekudaro, Dupras anoyambira kuti makambani anofanirwa kungwarira kuti asataure zvakanyanyisa pamusoro pezvakanakira bvunzo idzi. Uyezve, hazvizivikanwe kana bvunzo idzi, dziri nyowani, dzinokurudzira vanhu kuita sarudzo dzine hutano.

Muedzo unogona 6u466

Eric Verdin, purezidhendi uye CEO weBuck Institute for Research on Aging muNovato, California, akaratidza kufarira kwake mukana webvunzo dzekuchembera uye akaburitsa pachena kuti chikoro chake nderimwe remapoka akati wandei ari kugadzira bvunzo dzakadai.

"Zvishandiso zvakanakisa zvekutsvagisa, asi zvichiri kumberi kuti uzviise pachena."

Eric Verdin, mutungamiri uye CEO weBuck Institute for Research on Aging.

Maererano naye, chekutanga, hazvisi pachena kana bvunzo dzese dziripo pamusika dzakasimbiswa nemamwe masayendisiti. Uyezve, Verdin anoyambira kuti bvunzo idzi hadzisati dzaongororwa neUS Food and Drug istration uye, naizvozvo, hazvina kudzorwa.

Sinclair anotenda kuti hapana chinokanganisa kuziva zera rako rekubereka. "Kana uchinge wawana nhamba iyoyo, zvinoita sekunge une pani pamuviri wako," akadaro. "Tinotenda izvi zvinokupa simba uye kutsunga kuita shanduko muhupenyu hwako."

Muchidimbu, kunyangwe mukana wekuziva zera rako rekubereka uchigona kukurudzira kuti utore tsika dzine hutano, unofanirwa kuyeuka kuti bvunzo idzi dzichiri dzazvino uye dzinoda kusimbiswa. Naizvozvo, usati waitwa bvunzo yekuchembera yebiology, zvakakosha tsvaga mazano kuna chiremba uye nesainzi kuti tinzwisise zviri nani ganhuriro dzayo uye zvinogoneka.

Yakaongororwa na Dácio Castelo Branco musi wa 10/04/2023

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Kunobva: The Guardian, Wired, Tally Health, sainzi, Vadivelu Comedy TechnologyReview